DelveInsight’s ‘ICOS-Next Generation Immunotherapy Competitive Landscape and Market Forecast–2035’ report delivers an in-depth understanding of the ICOS as well as the market trends of ICOS-Next Generation Immunotherapy in the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.
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Some facts of ICOS-Next Generation Immunotherapy competitive report are:
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ICOS-Next Generation Immunotherapy Overview:
Cancer immunotherapy (CI) is rapidly advancing and can now be considered to be the “fifth pillar” of cancer therapy, joining the ranks of surgery, cytotoxic chemotherapy, radiation, and targeted therapy. The CI which has sparked the most interest involves antibodies to inhibitory immune checkpoint molecules.
Inducible co-stimulator (ICOS) is a specific T cell co-stimulatory molecule of the CD28/CTLA-4 family mainly expressed by CD4 T cells. It is a co-stimulator of proliferation and cytokine production by these cells. Its levels are upregulated in activated T lymphocytes, especially after the use of anti-CTLA4 therapies, and its expression is considered as a biomarker to indicate that anti-CTLA4 agents are binding its target.
Scope of the ICOS-Next Generation Immunotherapy market report
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ICOS-Next Generation Immunotherapy Emerging Drugs
GSK3359609: GlaxoSmithKline
GSK3359609, an inducible T cell co-stimulatory (ICOS) agonist antibody is designed to selectively enhance T cell function. After the administration, anti-ICOS agonist antibody GSK3359609 targets and binds to ICOS expressed on tumor-infiltrating CD4-positive T cells. This stimulates ICOS-positive T-cell proliferation which enhances cytotoxic T-lymphocyte (CTL) survival and increases CTL-mediated immune responses against tumor cells. ICOS, a T-cell specific, CD28-superfamily costimulatory molecule, and immune checkpoint protein is normally expressed on certain activated T cells and plays a key role in the proliferation and activation of T cells.
Vopratelimab: Jounce Therapeutics
Vopratelimab (also known as JTX-2011) is a clinical-stage monoclonal antibody that binds and activates ICOS, the Inducible T cell CO-Stimulator which is a protein present on the surface of certain T cells found in many solid tumors. The drug is currently in phase II (EMERGE) clinical trial in combination with ipilimumab in patients previously treated with PD-1/PD-L1 inhibitor therapies. The product candidate, JTX-2011, is a clinical-stage monoclonal antibody that binds to and activates ICOS, a protein on the surface of certain T cells commonly found in many solid tumors.
Table of Contents:
1. Key Insights
2. Executive Summary
3. Competitive Intensity of ICOS-Next Generation Immunotherapy
4. Market Competition of ICOS-Next Generation Immunotherapy
5. Technological innovations in ICOS-Next Generation Immunotherapy
6. Multivariate analysis of the key players in ICOS-Next Generation Immunotherapy
7. ICOS-Next Generation Immunotherapy Market Overview at a Glance
7.1. Market Share (%) Distribution of Next-Generation Immunotherapy in 2035
8. Pipeline Therapeutics Analysis (Active Products)
9. Overview: Next Generation Immunotherapy
10. Future Prospects and Challenges in ICOS-Next Generation Immunotherapy
10.1. Current Clinical Challenges in Immunotherapies
10.2. Future direction of improving response rates of Immunotherapy
11. SWOT Analysis
12. ICOS-Next Generation Immunotherapy Epidemiology and Forecasting Assumptions
13. Emerging ICOS-Next Generation Immunotherapy Drugs
13.2. GSK3359609: GlaxoSmithKline
13.3. Vopratelimab (JTX-2011): Jounce Therapeutics
13.4. KY1044: Kymab
13.5. BMS-986226 (Anti-ICOS): Bristol-Myers Squibb
13.6. XmAb23104: Xencor
14. Assessment by Indication Type
15. Assessment by Route of Administration
16. ICOS-7 Major Market Analysis
17. ICOS-Next Generation Immunotherapy Market Drivers
18. ICOS-Next Generation Immunotherapy Market Barriers
19. Appendix
19.1. Report Methodology
20. DelveInsight Capabilities
21. Disclaimer
22. About DelveInsight
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