DelveInsight, a leading market research firm, announces the release of its latest report, “DelveInsight’s Alpha-1 Antitrypsin Deficiency (AATD) Market Insights, Epidemiology, and Market Forecast 2034.” This comprehensive report provides an in-depth understanding of Alpha-1 Antitrypsin Deficiency, including historical and forecasted epidemiology, market trends, and treatment scenarios across the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom, and Japan.
Key Takeaways from the Alpha-1 Antitrypsin Deficiency Market
The market size for Alpha-1 Antitrypsin Deficiency in the leading markets is expected to grow significantly by 2034.
The United States accounted for the highest Alpha-1 Antitrypsin Deficiency treatment market size in 7MM in 2024, in comparison to the other major markets, i.e., EU4 countries, the United Kingdom, and Japan.
Based on DelveInsight’s assessment in 2024, the 7MM had approximately 225,950 prevalent cases of AATD, which are expected to rise during the forecast period (2025–2034).
According to DelveInsight’s analysis, the number of prevalent cases of AATD in the US was estimated to be nearly 134,340 in 2024.
Data suggests that the majority of AATD patients remain undiagnosed, with nearly 90% of cases being missed, while only 5–10% of patients receive a confirmed diagnosis.
In 2024, Japan accounted for approximately 2,950 cases of AATD, with prevalence significantly lower compared to the US and Europe.
Leading Alpha-1 Antitrypsin Deficiency companies, such as Kamada Pharmaceuticals, Arrowhead Pharmaceuticals and Takeda, Mereo BioPharma/AstraZeneca, Sanofi/Inhibrx Biosciences, Wave Life Sciences, Beam Therapeutics, Grifols, Krystal Biotech, BioMarin, AlveoGene, Korro Bio, Spexis/Santhera Pharmaceutical, and others, are developing new Alpha-1 Antitrypsin Deficiency treatment drugs that can be available in the Alpha-1 Antitrypsin Deficiency market in the coming years.
The promising Alpha-1 Antitrypsin Deficiency therapies in clinical trials include Fazirsiran (ARO-AAT/TAK-999), Inhaled Alpha 1-Antitrypsin (AAT), Alvelestat (MPH-966), INBRX-101/SAR447537, WVE-006, KB408, BEAM-302, Alpha-1 AT 15%, and others.
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Key Factors Driving the Alpha-1 Antitrypsin Deficiency Market
Rising Awareness and Diagnosis Rates:
Increasing awareness among healthcare professionals and the growing use of genetic and biomarker-based diagnostic testing are improving the diagnosis of AATD. Enhanced screening for patients with COPD, emphysema, and liver disorders is expected to contribute to market growth.
Growing Advancements in Gene and RNA-based Therapies:
Emerging therapies targeting the root cause of AATD through RNA interference, RNA editing, gene correction, and inhaled protein replacement approaches are transforming the treatment landscape. Therapies such as Fazirsiran, WVE-006, and BEAM-302 are attracting significant market attention due to their potential disease-modifying and curative capabilities.
Increasing Demand for Improved and Convenient Treatment Approaches:
Current augmentation therapies require frequent intravenous administration and are associated with high treatment burden. New inhaled, oral, subcutaneous, and self-administered therapies are expected to improve patient compliance, convenience, and quality of life.
Alpha-1 Antitrypsin Deficiency Competitive Landscape
Several Alpha-1 Antitrypsin Deficiency drugs in development include Fazirsiran (ARO-AAT/TAK-999) (Arrowhead Pharmaceuticals and Takeda), Inhaled Alpha 1-Antitrypsin (AAT) (Kamada Pharmaceuticals), Alvelestat (MPH-966) (Mereo BioPharma/AstraZeneca), INBRX-101/SAR447537 (Sanofi/Inhibrx Biosciences), WVE-006 (Wave Life Sciences), KB408 (Krystal Biotech), and BEAM-302 (Beam Therapeutics).
These candidates target diverse mechanisms such as reduction of mutant Z-AAT protein production, immunomodulation through inhaled AAT replacement, neutrophil elastase inhibition, RNA editing, and gene correction technologies, aiming to provide long-term disease modification with improved efficacy and convenience compared to current augmentation therapies.
Discover more about therapies set to grab major Alpha-1 Antitrypsin Deficiency market share @ Alpha-1 Antitrypsin Deficiency Treatment Landscape
Recent Developments in the Alpha-1 Antitrypsin Deficiency Market
In March 2025, the FDA approved an update to GLASSIA’s US Prescribing Information to include 1-, 4-, and 5-gram single-dose vials, available from July 2025, aiming to simplify weight-based dosing and improve convenience for patients.
In November 2024, Korro Bio announced submission to the Bellberry HREC for a Phase I/II clinical study of KRRO-110 for AATD.
In October 2024, Wave Life Sciences highlighted proof-of-mechanism data for WVE-006 for the treatment of AATD during Annual Research Day 2024.
In September 2024, Krystal Biotech amended the protocol for its KB408 Phase I SERPENTINE-1 study to include mandatory bronchoscopies for measuring alpha-1 antitrypsin expression.
In July 2024, Beam Therapeutics entered into a settlement agreement related to BEAM-302 development and commercialization activities.
According to Takeda’s FY2024 presentation released in May 2025, the company anticipates regulatory submissions for Fazirsiran in AATD-related liver disease between 2027 and 2029.
What is Alpha-1 Antitrypsin Deficiency?
Alpha-1 Antitrypsin Deficiency (AATD) is a rare inherited genetic disorder caused by mutations in the SERPINA1 gene, leading to low levels or dysfunctional alpha-1 antitrypsin protein in the blood. The condition primarily affects the lungs and liver, resulting in diseases such as emphysema, chronic obstructive pulmonary disease (COPD), cirrhosis, and liver failure. AATD is often underdiagnosed because its symptoms resemble those of asthma, COPD, and other liver disorders. Early diagnosis and appropriate management are essential to improve patient outcomes and quality of life.
Alpha-1 Antitrypsin Deficiency Epidemiology Segmentation
The Alpha-1 Antitrypsin Deficiency epidemiology section provides insights into the historical and current Alpha-1 Antitrypsin Deficiency patient pool and forecasted trends for the leading markets. The Alpha-1 Antitrypsin Deficiency market report proffers epidemiological analysis for the study period 2020–2034 in the leading markets, segmented into:
Total Prevalent Cases of Alpha-1 Antitrypsin Deficiency
Total Diagnosed Prevalent Cases of Alpha-1 Antitrypsin Deficiency
Genotype-specific Cases of Alpha-1 Antitrypsin Deficiency
Comorbidity-associated Cases of Alpha-1 Antitrypsin Deficiency
Scope of the Alpha-1 Antitrypsin Deficiency Market Report
Therapeutic Assessment: Alpha-1 Antitrypsin Deficiency current marketed and emerging therapies
Alpha-1 Antitrypsin Deficiency Market Dynamics: Key Market Forecast Assumptions of Emerging Alpha-1 Antitrypsin Deficiency Drugs and Market Outlook
Key Companies: Kamada Pharmaceuticals, Arrowhead Pharmaceuticals and Takeda, Mereo BioPharma/AstraZeneca, Sanofi/Inhibrx Biosciences, Wave Life Sciences, Beam Therapeutics, Grifols, Krystal Biotech, BioMarin, AlveoGene, Korro Bio, Spexis/Santhera Pharmaceutical, and others
Key Therapies: Fazirsiran (ARO-AAT/TAK-999), Inhaled Alpha 1-Antitrypsin (AAT), Alvelestat (MPH-966), INBRX-101/SAR447537, WVE-006, KB408, BEAM-302, Alpha-1 AT 15%, PROLASTIN-C LIQUID/LYNSPAD, ZEMAIRA/RESPREEZA, GLASSIA, ARALAST NP, and others
Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
Unmet Needs, KOL’s views, Analyst’s views, Alpha-1 Antitrypsin Deficiency Market Access and Reimbursement
To know more about Alpha-1 Antitrypsin Deficiency companies working in the treatment market, visit @ Alpha-1 Antitrypsin Deficiency Clinical Trials and Therapeutic Assessment
Table of Contents
Alpha-1 Antitrypsin Deficiency Market Report Introduction
Executive Summary for Alpha-1 Antitrypsin Deficiency
SWOT Analysis of Alpha-1 Antitrypsin Deficiency
Alpha-1 Antitrypsin Deficiency Patient Share (%) Overview at a Glance
Alpha-1 Antitrypsin Deficiency Market Overview at a Glance
Alpha-1 Antitrypsin Deficiency Background and Overview
Alpha-1 Antitrypsin Deficiency Epidemiology and Patient Population
Country-Specific Patient Population of Alpha-1 Antitrypsin Deficiency
Alpha-1 Antitrypsin Deficiency Current Treatment and Medical Practices
Alpha-1 Antitrypsin Deficiency Unmet Needs
Alpha-1 Antitrypsin Deficiency Emerging Therapies
Alpha-1 Antitrypsin Deficiency Market Outlook
Country-Wise Alpha-1 Antitrypsin Deficiency Market Analysis (2020–2034)
Alpha-1 Antitrypsin Deficiency Market Access and Reimbursement of Therapies
Alpha-1 Antitrypsin Deficiency Market Drivers
Alpha-1 Antitrypsin Deficiency Market Barriers
Alpha-1 Antitrypsin Deficiency Appendix
Alpha-1 Antitrypsin Deficiency Report Methodology
DelveInsight Capabilities
Disclaimer
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